GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs2985684 | 1 | rs2985687 | chr14:50100386 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs2985684 | 1 | rs2985696 | chr14:50094913 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs2985684 | 1 | rs2985697 | chr14:50092902 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs4660306 | 1 | rs2993259 | chr1:46001550 | CCDC163P | chr1:45960581-45965646:- | -0.72 | -7.69 | 2.83E-10 | Homocysteine levels |
| UVM | cis | rs2985684 | 1 | rs3007030 | chr14:50086563 | RPL36AL | chr14:50085407-50087349:- | 0.48 | 4.75 | 1.49E-5 | Carotid intima media thickness |
| UVM | cis | rs2985684 | 1 | rs3007031 | chr14:50102269 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs10461617 | 1 | rs3099459 | chr5:56137170 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.34 | 4.59E-8 | Type 2 diabetes |
| UVM | cis | rs8078723 | 1 | rs3213762 | chr17:38178627 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.62 | 3.69E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs9876781 | 1 | rs3214041 | chr3:48454468 | TREX1 | chr3:48501186-48509043:+ | -0.39 | -5.06 | 5.03E-6 | Longevity |
| UVM | cis | rs10461617 | 1 | rs33322 | chr5:56175226 | C5orf35 | chr5:56205103-56213010:+ | 0.9 | 5.67 | 5.41E-7 | Type 2 diabetes |
| UVM | cis | rs10461617 | 1 | rs33325 | chr5:56142547 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.34 | 4.59E-8 | Type 2 diabetes |
| UVM | cis | rs10461617 | 1 | rs33326 | chr5:56142601 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.34 | 4.59E-8 | Type 2 diabetes |
| UVM | cis | rs78153629 | 1 | rs34088794 | chr15:40665420 | C15orf23 | chr15:40674922-40686488:+ | 0.92 | 6.6 | 1.72E-8 | Heschl's gyrus morphology |
| UVM | cis | rs2564921 | 1 | rs34530577 | chr3:53103796 | RFT1 | chr3:53122503-53164470:- | -0.37 | -5.39 | 1.5E-6 | Height |
| UVM | cis | rs13008299 | 1 | rs34878079 | chr2:29248199 | FAM179A | chr2:29204164-29275094:+ | 0.72 | 5.51 | 9.95E-7 | Diastolic blood pressure (alcohol consumption interaction) |